The omicron virus variant: What it is, why scientists are concerned and what we still don’t know

WHAT IS THIS NEW COVID-19 VARIANT IN SOUTH AFRICA?

South African scientists identified a new version of the coronavirus this week that they say is behind a recent spike in COVID-19 infections in Gauteng, the country’s most populous province. It’s unclear where the new variant first emerged, but scientists in South Africa first alerted the World Health Organization and it has now been seen in travelers to Belgium, Botswana, Hong Kong and Israel.

Health Minister Joe Phaahla said the variant was linked to an “exponential rise” of cases in the last few days, although experts are still trying to determine if the new variant is actually responsible.

From just over 200 new confirmed cases per day in recent weeks, South Africa saw the number of new daily cases rocket to 2,465 on Thursday. Struggling to explain the sudden rise in cases, scientists studied virus samples from the outbreak and discovered the new variant.

In a statement on Friday, the World Health Organization designated it as a “variant of concern,” naming it “Omicron” after a letter in the Greek alphabet.

After convening a group of experts to assess the data, the U.N. health agency said that “preliminary evidence suggests an increased risk of reinfection with this variant,” as compared to other variants.

“The number of cases of this variant appears to be increasing in almost all provinces in South Africa,” the WHO said.

WHY ARE SCIENTISTS WORRIED ABOUT THIS NEW VARIANT?

It appears to have a high number of mutations — about 30 — in the coronavirus’ spike protein, which could affect how easily it spreads to people.

Sharon Peacock, who has led genetic sequencing of COVID-19 in Britain at the University of Cambridge, said the data so far suggest the new variant has mutations “consistent with enhanced transmissibility,” but said that “the significance of many of the mutations is still not known.”

Lawrence Young, a virologist at the University of Warwick, described omicron as “the most heavily mutated version of the virus we have seen,” including potentially worrying changes never before seen all in the same virus.

Dr. Anthony Fauci, the U.S.’ top infectious diseases doctor, said American officials had arranged a call with their South African counterparts later on Friday to find out more details and said there was no indication the variant had yet arrived in the U.S.

[New omicron variant emerging from southern Africa stokes world fears, triggers travel bans]

WHAT’S KNOWN AND NOT KNOWN ABOUT THE VARIANT?

Scientists know that omicron is genetically distinct from previous variants including the beta and delta variants, but do not know if these genetic changes make it any more transmissible or dangerous. So far, there is no indication the variant causes more severe disease.

It will likely take weeks to sort out if omicron is more infectious and if vaccines are still effective against it.

Peter Openshaw, a professor of experimental medicine at Imperial College London said it was “extremely unlikely” that current vaccines wouldn’t work, noting they are effective against numerous other variants.

Even though some of the genetic changes in omicron appear worrying, it’s still unclear if they will pose a public health threat. Some previous variants, like the beta variant, initially alarmed scientists but didn’t end up spreading very far.

“We don’t know if this new variant could get a toehold in regions where delta is,” said Peacock of the University of Cambridge. “The jury is out on how well this variant will do where there are other variants circulating.” To date, delta is by far the most predominant form of COVID-19, accounting for more than 99% of sequences submitted to the world’s biggest public database.

HOW DID THIS NEW VARIANT ARISE?

The coronavirus mutates as it spreads and many new variants, including those with worrying genetic changes, often just die out. Scientists monitor COVID-19 sequences for mutations that could make the disease more transmissible or deadly, but they cannot determine that simply by looking at the virus.

Peacock said the variant “may have evolved in someone who was infected but could then not clear the virus, giving the virus the chance to genetically evolve,” in a scenario similar to how experts think the alpha variant — which was first identified in England — also emerged, by mutating in an immune-compromised person.

ARE THE TRAVEL RESTRICTIONS BEING IMPOSED BY SOME COUNTRIES JUSTIFIED?

Maybe. As of noon Friday, travelers arriving in the U.K. from South Africa, Namibia, Botswana, Lesotho, Eswatini and Zimbabwe will have to self-isolate for 10 days. European Union nations also moved quickly on Friday to ban air travel from southern Africa, and the U.S. also said it would ban travel from South Africa and seven other African nations by non-US citizens beginning Monday.

Given the recent rapid rise in COVID-19 in South Africa, restricting travel from the region is “prudent” and would buy authorities more time, said Neil Ferguson, an infectious diseases expert at Imperial College London.

Jeffrey Barrett, director of COVID-19 Genetics at the Wellcome Sanger Institute, thought that the early detection of the new variant could mean restrictions taken now would have a bigger impact than when the delta variant first emerged

“With delta, it took many, many weeks into India’s terrible wave before it became clear what was going on and delta had already seeded itself in many places in the world and it was too late to do anything about it,” he said. “We may be at an earlier point with this new variant so there may still be time to do something about it.”